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KMID : 0357919850190020194
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Korean Journal of Pathology
1985 Volume.19 No. 2 p.194 ~ p.201
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Metastatic Giant Cell Carcinoma of Thyroid Simulating Primary Small Intestinal Tumor-Report of a case with ultrastructural and immunohistochemical studies-
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Abstract
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We present a case of metastatic giant cell carcinoma of the thyroid in small intestine
presenting as an unusual polypoid growth, and its ultrastructure and
immunohistochemical reaction to thyroglobulin were investigated.
The patient was a 63 years old female who raceived a segmental resection of ileum
for intestinal obstruction, one year after a radical neck dissection and thyroidectomy for
anaplastic(giant cell variant) carcinoma with a focus of papillary tumor of the thyroid. In
the segmentally resected ileum, there were three conglomerated round intraluminal
polypoid tumor masses in close approximation which measured 4.5㎝, 2.5㎝ and 2㎝
respectively. The histological features were similar to those of thyroid lesion, being
predominantly made of anaplastic giant and spindle cells in haphazard arrangement.
Ultrastructure of pleomorphic spindle cells and multinucleated giant cells demonstrated
numerous mitochondria with tubular cristae, rough endoplasmic reticula and a few
membrane-bound dense granules. Peroxidase-antiperoxidase method against thyroglobulin
revealed strong positive staining on papillary carcinoma and weak positivity on both
giant cells and spindle cells of the anaplastic carcinoma. The above observations confirm
that multinucleated giant cells of small intestine originate from metastatic giant cell
carcinoma of the thyroid.
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KEYWORD
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